Is this a pistol your wife will carry either often or frome time to time? The Keltec is light but the heights is 5.3 inches which may be inconvenient for concealed carry. If this is a home defense or "in the car" pistol it doesn't matter. She might also consider the Taurus TX22 Compact. I have the Competition SCR version and the upper for the Standard size. It is very reliable and accurate. And as stated above she will need more than one shot. It will take 3-4 to produce the energy of a good 9mm self defense round. I would stay with CCI such as the 40gr MM (hollow point is a wasted effort) or the Velocitor if it works. But it looks to me the newest trend is the compact size and subcompact size .380. A weakened 9mm but there has been major progress in developing workable self defense rounds in .380. I pocket carry a Glock 42 with Underwood Extreme Defenders, a 68gr round. It doesn't rely on velocity for hollow point performance. Check out some YT channels on this round's performance. For carry I would suggest she try the Glock 42 and Sig 365 .380. I choose the G42 but Sig has it's advantages as well. My 42 is small and light enough for pocket carry but is very easy to shoot and control recoil for multiple shots. If she wants something a bit larger and not as easy to conceal, look at the Ruger Security .380 and S&W EZ .380. I think the Ruger Security .380 is the real sleeper of the group for a "shooter", but it is too large and heavy for me to pocket carry. YMMV. I think the new "trend" is the .380 with significant bullet performance and increased size from the traditional "mouse size" .380 pistols. Having said all this if she will and wants to shoot only a .22lr find a reliable one, (my Taurus has been), shoot as reliable .22 ammo as you can find, probably CCI 40gr MM, and shoot the heck out of it-often. The advantage of the .22 is you can actually afford to shoot lots of it.=getting really, really good with that pistol. I spoke with a lady in my church yesterday and found out she carries a .25 Browning. She said she had to pull it twice and disengage the safety once! I was impressed. Never thought she would be carrying. What is significant is she had a gun, knew how to use it and was prepared to do so. Fortunately she didn't have to fire, just having it was sufficient. I wouldn't hesitate to use my Taurus if I needed to. I can put a lot of rounds in a 6" target at 25 yards shooting as quickly as I regain a good sight picture. Death by a thousand bee stings!