Glock 17. Totally reliable, accurate and carries 18 rounds of 9mm+p as my primary home defense firearm.
I've never been a big 1911 fan. I'll add that I would not part with my Ruger P97dc which would replace the Glock 17 should the Glock ever have to go to the gunsmith for any reason.
I currently don't have a full size. (Unless you consider a Redhawk) When in LE I carried a S&W 4506-.45 ACP. I foolishly sold it several years after separating from the S. O.
Medium: Keltec P-11, 9x19
Small: Ruger LCP, 9x17
gramps
Ditched all my semi autos a couple weeks ago except 3 Colt 1911's and a Gold Cup. Medium sized I carry a 2 inch Model 19 no dash. I got rid of all my bug autos too.